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UCES

Understanding Cauda Equina Syndrome (UCES) Study

Trainee Lead

Julie Woodfield

Aimun Jamjoom

Ingrid Hoeritzauer

​Understanding cauda equina syndrome: protocol for a UK multicentre prospective observational cohort study. Woodfield J, Hoeritzauer I, Jamjoom AAB, Pronin S, Srikandarajah N, Poon M, Roy H, Demetriades AK, Sell P, Eames N, Statham PFX; British Neurosurgical Trainee Research Collaborative (BNTRC). BMJ Open. 2018 Dec 14;8(12):e025230.

UK Chiari 1 Study (UK-C1S)

Trainee Lead

Rory Piper

Fardad Afshari

UK Chiari 1 Study: protocol for a prospective, observational, multicentre study​. Piper RJ, Afshari FT, Soon WC, Kolias AG, Dyson EW, Watkins L, Laing R, Lo WB, Jayamohan J; British Neurosurgical Trainee Research Collaborative (BNTRC). BMJ Open. 2021 Apr 12;11(4):e043712. doi: 10.1136/bmjopen-2020-043712. PMID: 33846149; PMCID: PMC8048021.

UK Cranial Reconstruction Registry (UK-CRR)

Trainee Lead

Daniel Fountain

Ellie Edlmann

First Report of a Multicenter Prospective Registry of Cranioplasty in the United Kingdom and Ireland. Fountain DM, Henry J, Honeyman S, O'Connor P, Sekhon P, Piper RJ, Edlmann E, Martin M, Whiting G, Turner C, Mee H, Joannides AJ, Kolias AG, Hutchinson PJ; UK Cranial Reconstruction Registry (UKCRR) Collaborative; British Neurosurgical Trainee Research Collaborative (BNTRC). Neurosurgery. 2021 Aug 16;89(3):518-526. doi: 10.1093/neuros/nyab220. PMID: 34192745.

Proposal for establishment of the UK Cranial Reconstruction Registry (UKCRR). Kolias AG, Bulters DO, Cowie CJ, Wilson MH, Afshari FT, Helmy A, Broughton E, Joannides AJ, Zebian B, Harrisson SE, Hill CS, Ahmed AI, Barone DG, Thakur B, McMahon CJ, Adlam DM, Bentley RP, Tolias CM, Mitchell PM, Whitfield PC, Critchley GR, Belli A, Brennan PM, Hutchinson PJ; British Neurosurgical Trainee Research Collaborative.; British Neurotrauma Group.; UKCRR Collaborative Group. Br J Neurosurg. 2014 Jun;28(3):310-4. doi: 10.3109/02688697.2013.859657. PubMed PMID: 24237069.

Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and MRI Tests (IMPACT)

Trainee Lead

Abed Islim

Chris Millward

External validation and recalibration of an incidental meningioma prognostic model – IMPACT: protocol for an international multicentre retrospective cohort study. Islim AI, Millward CP, Piper RJ, Fountain DM, Mehta S, Kolamunnage-Dona R, Ali U, Koszdin SD, Georgious T, Mills SJ, Brodbelt AR, Mathew RK, Santarius T, Jenkinson MD; IMPACT Study Investigators, International Consortium on Meningioma (ICOM) and British Neurosurgical Trainee Research Collaborative (BNTRC). BMJ Open. 2022 Jan 18;12(1):e052705. doi: 10.1136/bmjopen-2021-052705. PMID: 35042706; PMCID: PMC8768908.

Chronic Subdural Haematoma Audit

Trainee Lead

Paul M Brennan

Ian C Coulter

Angelos G Kolias

Drains result in greater reduction of subdural width and midline shift in burr-hole evacuation of chronic subdural haematoma. Glancz LJ, Poon MTC, Kolias AG, Huthcinson PJ, Brennan PM, British Neurosurgical Trainee Research Collaborative (BNTRC). Acta Neurochirurgica. [Accepted 31Mar2020]

Time to surgery following chronic subdural hematoma: post hoc analysis of a prospective cohort study. Venturini S, Fountain DM, Glancz LJ, Livermore LJ, Coulter IC, Bond S, Matta B, Santarius T, Hutchinson PJ, Brennan PM, Kolias AG, British Neurosurgical Trainee Research Collaborative (BNTRC).  BMJ Surgery, Intervention, and Health Technologies. Dec 2019.

 

Influence of Antiplatelet and Anticoagulant Drug Use on Outcomes after Chronic Subdural Hematoma Drainage. Poon MTC, Rea C, Kolias AG, Brennan PM; British Neurosurgical Trainee Research Collaborative (BNTRC).  J Neurotrauma. 2019 Jan 30. doi: 10.1089/neu.2018.6080. [Epub ahead of print]

Does Drain Position and Duration Influence Outcomes in Patients Undergoing Burr-Hole Evacuation of Chronic Subdural Hematoma? Lessons from a UK Multicenter Prospective Cohort Study. Glancz LJ, Poon MTC, Coulter IC, Hutchinson PJ, Kolias AG, Brennan PM; British Neurosurgical Trainee Research Collaborative (BNTRC). Neurosurgery. 2018 Aug 29. [Epub ahead of print]

Outcomes following surgery in subgroups of comatose and very elderly patients with chronic subdural hematoma. Christopher E, Poon MTC, Glancz LJ, Hutchinson PJ, Kolias AG, Brennan PM; British Neurosurgical Trainee Research Collaborative (BNTRC).  Neurosurg Rev. 2018 Apr 21. [Epub ahead of print]

The management and outcome for patients with chronic subdural hematoma: a prospective, multicenter, observational cohort study in the United Kingdom.  Brennan PM, Kolias AG, Joannides AJ, Shapey J, Marcus HJ, Gregson BA, Grover PJ, Hutchinson PJ, Coulter IC;  on behalf of the British Neurosurgical Trainee Research Collaborative. J Neurosurg. 2016 Nov 11:1-8. [Epub ahead of print] PubMed PMID: 27834599.

Chronic subdural haematoma: How can we improve patient care and outcomes? Kolias AG, Coulter IC, Marcus HJ, Gray WP, Brennan PM, Hutchinson PJ; British Neurosurgical Trainee Research Collaborative. Br J Neurosurg. 2014 Jan;28(1):136-7. doi: 10.3109/02688697.2013.869555. PubMed PMID: 24325139.

Proposal for a prospective multi-centre audit of chronic subdural haematoma management in the United Kingdom and Ireland. Coulter IC, Kolias AG, Marcus HJ, Ahmed AI, Alli S, Al-Mahfoudh R, Borg A, Cowie CJ, Hill CS, Joannides AJ, Jones TL, Kailaya-Vasan A, Livermore JL, Narayanamurthy H, Ngoga D, Shapey J, Tarnaris A, Gregson BA, Gray WP, Nelson RJ, Hutchinson PJ, Brennan PM; UK Neurosurgical Research Network, British Neurosurgical Trainee Research Collaborative. Br J Neurosurg. 2014 Apr;28(2):199-203. doi: 10.3109/02688697.2013.835378. PubMed PMID: 24053314.

External Ventricular Drainage Audit

Trainee Lead

Aminul Ahmed

Aimun A Jamjoom

Alexis Joannides

Utility of image-guided external ventriculostomy: analysis of contemporary practice in the United Kingdom and Ireland. McLean AL, Jamjoom AAB, Poon MTC, Wang D, Phang I, Okasha M, Boissaud-Cooke M, Williams AP, Ahmed AI; British Neurosurgical Trainee Research Collaborative. J Neurosurg. 2021 Jan 29:1-9. doi: 10.3171/2020.8.JNS20321. Epub ahead of print. PMID: 33513567.

Prospective, multicentre study of external ventricular drainage-related infections in the UK and Ireland. Jamjoom AAB, Joannides AJ, Poon MTC, Chari A, Zaben M, Abdulla MAH, Roach J, Glancz LJ, Solth A, Duddy J, Brennan PM, Bayston R, Bulters DO, Mallucci CL, Jenkinson MD, Gray WP, Kandasamy J, Hutchinson PJ, Kolias AG, Ahmed AI; British Neurosurgical Trainee Research Collaborative.  J Neurol Neurosurg Psychiatry. 2018 Feb;89(2):120-126.

External ventricular drainage: Is it time to look at national practice? Jamjoom AA, Kolias AG, Zaben M, Chari A, Kitchen J, Joannides A, Brennan PM, Kandasamy J, Gatscher S, Gray WP, Jenkinson MD, Bulters DO, Mallucci CL, Schuster H, Hutchinson PJ, Ahmed AI; UK Neurosurgical Research Network & British Neurosurgical Trainee Research Collaborative. Br J Neurosurg. 2014 Sep 4:1-2. [Epub ahead of print] PubMed PMID: 25188651.

Trial of Dexamethasone for Chronic Subdural Haematoma (Dex-CSDH)

Trainee Lead

Ellie Edlmann

Trial of Dexamethasone for Chronic Subdural Hematoma. Hutchinson PJ, Edlmann E, Butlers D, Zolnourian A, Holton P, Suttner N, Agyemang K, Thomson S, Anderson IA, Al-Tamimi YZ, Henderson D, Whitfield PC, Gherle M, Brennan PM, Allison A, Thelin EP, Tarantino S, Pantaleo B, Caldwell K, Davis-Wilkie C, Mee H, Warburton EA, Barton G, Chari A, Marcus HJ, King AT, Belli A, Myint PK, Wilkinson I, Santarius T, Turner C, Bond S, Kolias AG; British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators. N Engl J Med 2020; 383:2616-2627

Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase.  Edlmann E, Thelin EP, Caldwell K, Turner C, Whitfield P, Bulters D, Holton P, Suttner N, Owusu-Agyemang K, Al-Tamimi YZ, Gatt D, Thomson S, Anderson IA, Richards O, Gherle M, Toman E, Nandi D, Kane P, Pantaleo B, Davis-Wilkie C, Tarantino S, Barton G, Marcus HJ, Chari A, Belli A, Bond S, Gafoor R, Dawson S, Whitehead L, Brennan P, Wilkinson I, Kolias AG, Hutchinson PJA; Dex-CSDH trial collaborative and BNTRC collaborative. Sci Rep. 2019 Apr 10;9(1):5885.

 

Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial. Kolias AG, Edlmann E, Thelin EP, Bulters D, Holton P, Suttner N, Owusu-Agyemang K, Al-Tamimi YZ, Gatt D, Thomson S, Anderson IA, Richards O, Whitfield P, Gherle M, Caldwell K, Davis-Wilkie C, Tarantino S, Barton G, Marcus HJ, Chari A, Brennan P, Belli A, Bond S, Turner C, Whitehead L, Wilkinson I, Hutchinson PJ; British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators. Trials. 2018 Dec 4;19(1):670.

Management Evaluation of Metastasis in the Brain (MEMBRAIN)

Trainee Lead

Josephine Jung

Jignesh Tailor

Francesco Vergani

Management evaluation of metastasis in the brain (MEMBRAIN) - a United Kingdom and Ireland prospective, multicenter observational study. Jung J, Tailor J, Dalton E, Glancz L, Roach J, Zakaria R, Lammy S, Chari A, Budohoski KP, Livermore LJ, Yu K, Jenkinson MD, Brennan PM, Brazil L, Bunce C, Bourmpaki E, Ashkan K, Vergani, F, British Neurosurgical Trainee Research Collaborative. Neuro-Oncology Practice. 2019 December

Residual Enhancing Disease in Glioblastoma (RED-GB) Study

Trainee Lead

Ruichong Ma

Residual enhancing disease after surgery for glioblastoma: evaluation of practice in the United Kingdom. Ma R, Chari A, Brennan PM, Alalade A, Anderson I, Solth A, Marcus HJ, Watts C, British Neurosurgical Trainee Research Collaborative. Neuro-Oncology Practice. 2018 June pp74-81.

Non-aneurysmal Subarachnoid Haemorrhage (naSAH) Study

Trainee Lead

Aswin Chari

Subarachnoid haemorrhage with negative initial neurovascular imaging: a systematic review and meta-analysis.  Mohan M, Islim AI, Rasul FT, Rominiyi O, deSouza RM, Poon MTC, Jamjoom AAB, Kolias AG, Woodfield J, Patel K, Chari A, Kirollos R; British Neurosurgical Trainee Research Collaborative. Acta Neurochirurgica. 2019 Aug  13. doi: 10.1007/s00701-019-04025-w. [Epub ahead of print]

Advancing Collaborative Research

Trainee Lead

Aswin Chari

Paul M Brennan

Christopher Cowie

Angelos G Kolias

Delivering Large-Scale Neurosurgical Studies in the UK: The Impact of Trainees. Chari A, Piper RJ, Edlmann E, Woodfield J, Brennan PM, Turner C, Jenkinson MD, Hutchinson PJ, Kolias AG; British Neurosurgical Trainee Research Collaborative. Delivering Large-Scale Neurosurgical Studies in the UK: The Impact of Trainees. World Neurosurg. 2022 May;161:343-349. doi: 10.1016/j.wneu.2021.09.002. PMID: 35505553.

The British Neurosurgical Trainee Research Collaborative: Five years on. Chari A, Jamjoom AA, Edlmann E, Ahmed AI, Coulter IC, Ma R, May P, Brennan PM, Hutchinson PJA, Kolias AG; British Neurosurgical Trainee Research Collaborative. Acta Neurochir (Wien). 2018 Jan;160(1):23-28.

Ensuring a bright future for clinical research in surgery with trainee led research networks. Kolias AG, Cowie CJ, Tarnaris A, Hutchinson PJ, Brennan PM; British Neurosurgical Trainee Research Collaborative.. BMJ. 2013 Aug 21;347:f5225. doi: 10.1136/bmj.f5225. PubMed PMID: 23965517.

A report from the inaugural meeting of the British Neurosurgical Trainee Research Collaborative held in the Royal College of Surgeons of England. Kolias AG, Jones TL, Cowie CJ, Coulter IC, Afshari FT, Tarnaris A, Nelson RJ, Gray WP, Hutchinson PJ, Brennan PM; UK Neurosurgical Research Network.; British Neurosurgical Trainee Research Collaborative. 19 October 2012. Br J Neurosurg. 2013 Jun;27(3):307-10. doi: 10.3109/02688697.2013.781122. PubMed PMID: 23530715.

Proposal for a British neurosurgical trainee research collaborative. Kolias AG, Cowie CJ, Tarnaris A, Hutchinson PJ, Brennan PM. Br J Neurosurg. 2012 Jun;26(3):434-5. doi: 10.3109/02688697.2012.690920. PubMed PMID: 22583319.

BNTRC Supported Studies

Collaborator

SBNS

NANSIG

Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study. Gillespie CS, Bligh ER, Poon MTC, Solomou G, Islim AI, Mustafa MA, Rominiyi O, Williams ST, Kalra N, Mathew RK, Booth TC, Thompson G, Brennan PM, Jenkinson MD; INTERVAL-GB Collaborative; British Neurosurgical Trainee Research Collaborative (BNTRC); Neurology and Neurosurgery Interest Group (NANSIG); Neurology and Neurosurgery Interest Group. BMJ Open. 2022 Sep 13;12(9):e063043. doi: 10.1136/bmjopen-2022-063043. PMID: 36100297; PMCID: PMC9472166.

CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service. Fountain DM, Piper RJ, Poon MTC, Solomou G, Brennan PM, Chowdhury YA, Colombo F, Elmoslemany T, Ewbank FG, Grundy PL, Hasan MT, Hilling M, Hutchinson PJ, Karabatsou K, Kolias AG, McSorley NJ, Millward CP, Phang I, Plaha P, Price SJ, Rominiyi O, Sage W, Shumon S, Silva IL, Smith SJ, Surash S, Thomson S, Lau JY, Watts C, Jenkinson MD; British Neurosurgical Trainee Research Collaborative (BNTRC). Neurooncol Adv. 2021 Jan 28;3(1):vdab014. doi: 10.1093/noajnl/vdab014. PMID: 34056602; PMCID: PMC7928638.

CSF Rhinorrhoea After Endonasal Intervention to the Skull Base (CRANIAL) - Part 1: Multicenter Pilot Study. CRANIAL ConsortiumWorld Neurosurg. 2021 May;149:e1077-e1089. doi: 10.1016/j.wneu.2020.12.171. Epub 2021 Jan 11. PMID: 33444844; PMCID: PMC8105646.

CSF Rhinorrhea After Endonasal Intervention to the Skull Base (CRANIAL) - Part 2: Impact of COVID-19. CRANIAL Consortium. World Neurosurg. 2021 May;149:e1090-e1097. doi: 10.1016/j.wneu.2020.12.169. Epub 2021 Jan 11. PMID: 33444833; PMCID: PMC7965443.

CSF rhinorrhoea after endonasal intervention to the anterior skull base (CRANIAL): proposal for a prospective multicentre observational cohort study. Khan DZ, Bandyopadhyay S, Patel V, Schroeder BE, Cabrilo I, Choi D, Cudlip SA, Donnelly N, Dorward NL, Fountain DM, Grieve J, Halliday J, Kolias AG, Mannion RJ, O'Donnell A, Phillips N, Piper RJ, Ramachandran B, Santarius T, Sayal P, Sharma R, Solomou G, Tysome JR, Marcus HJ; Neurology and Neurosurgery Interest Group (NANSIG), British Neurosurgical Trainee Research Collaborative (BNTRC), and CRANIAL Steering Committee. Br J Neurosurg. 2021 Aug;35(4):408-417. doi: 10.1080/02688697.2020.1795622. Epub 2020 Sep 10. PMID: 32909855.

Evaluation of nationwide referral pathways, investigation and treatment of suspected cauda equina syndrome in the United Kingdom. Fountain DM, Davies SCL, Woodfield J, Kamel M, Majewska P, Edlmann E, Jamjoom AAB, Hoeritzauer I, Waqar M, Mahoney DE, Vyas D, Schramm MWJ, Solomou G, Dawkes FEC, Grant HK, Attwood JE, Boukas A, Ballard DJ, Toman E, Sanders MI, Cheserem B, Sinha S, Statham P; British Neurosurgical Trainee Research Collaborative; Neurology and Neurosurgery Interest Group. Br J Neurosurg. 2019;0(0):1-11. doi: 10.1080/02688697.2019.1648757. PMID: 31407596.

UK-CRR
UK-C1S
IMPACT
CSDH audit
EVD audit
Dex-CSDH
Mets
RED-GB
naSAH
Supported projects
Advancing collaborton
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